Pluto Bioinformatics

GSE99247: Differential Gene Expression and Pathway Analysis in Juvenile Nasopharyngeal Angiofibroma Using RNA-Sequencing

Bulk RNA sequencing

We have identified a set of differentially expressed genes in the juvenile nasopharyngeal angiofibroma transcriptome and predict activation of the vascular endothelial growth factor and interleukin-6 signaling pathways, which represent potential molecular targets for therapy in patients with inoperable or persistent disease. These results implicate the role of fibroblasts as a tumor cell type driving disease progression. SOURCE: Sufi,Mary,Thomas (sthomas7@kumc.edu) - 4031 Wahl Hall East University of Kansas Medical Center