Pluto Bioinformatics

GSE99076: Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint

Bulk RNA sequencing

To elucidate the molecular bases for the infertile phenotype of Zmym3 KO mice at the mRNA expression level, we carried out RNA sequencing (RNA-seq) analysis on cultured spermatogonial stem cells (SSCs), c-KIT+ pre-meiotic cells induced from SSCs and spermatocytes directly isolated from adult mouse testes. SOURCE: Chunsheng Han (hancs@ioz.ac.cn) - State Key Laboratory of Reproductive Biology Chinese Academy of Sciences