Pluto Bioinformatics

GSE98822: Constitutive and Tamoxifen inducible knockout of HDAC1 and HDAC2 in Microglia

Bulk RNA sequencing

Hdac1 and 2 are important regulators of developmental processes. In this study we created microglia specific compound Hdac1 and Hdac2 knock out mice. Pre-natal ablation of both Hdac1 and 2 from microglia leads to reduced cell number and altered cell morphology. To investigate how Hdac1 and 2 knock out in microglia alters cellular gene expression profile we carried out RNA-seq analysis at different time points. SOURCE: Ori Staszewski (ori.staszewski@uniklinik-freiburg.de) - University Medical Center Freiburg