Pluto Bioinformatics

GSE98768: Histone H3.1K27 methylation promotes NHEJ by antagonizing FANCD2 on Chromatin

Bulk RNA sequencing

The goals of this project are to study the transcriptome profiling (RNA-seq) of human fribroblast cells undergoing H3K27me3 decrease by histone mutants incorporation (H3.1K27A/M vs H3.1wt) or shRNA-mediated knockdown of specific histone H3K27me3 methyl-transferase EZH2 (shEZH2 vs shNC) SOURCE: Jin Sun (sunjin@tongji.edu.cn) - Jiang Tongji University