Tfam inactivation by Nkx2.5Cre caused embryonic lethal myocardial hypoplasia. Tfam inactivation was accompanied by elevated production of reactive oxygen species (ROS) and reduced cardiomyocyte proliferation. Mosaic embryonic Tfam inactivation confirmed that the block to cardiomyocyte proliferation was cell autonomous. Transcriptional profiling by RNA-seq demonstrated activation of the DNA damage pathway. SOURCE: Fei Gu (alickgf@hotmail.com) - William Pu Childrens hospital boston, Harvard Medical School

Pluto Bioinformatics

GSE98579: RNAseq for Tfam knock under NKX2.5 promoter