Pluto Bioinformatics

GSE95712: Bmal1 regulates inflammatory response in macrophage

Bulk RNA sequencing

Deletion of Arntl disrupted temporal inflammatory response in macrophage. Mechanistically, the acetylation status of lysine 27 of histone 3 (H3K27ac) was enhanced at the PU.1-containing enhancers in Arntl-/- macrophages compared to the wild-type cells. Collectively, transcription factor network containing Bmal1 controls temporal inflammatory response of macrophages by regulating epigenetic states of enhancers. SOURCE: Yumiko Oishi (yuooishi-circ@umin.ac.jp) - Tokyo Medical and Dental University