Pluto Bioinformatics

GSE95500: Celecoxib, Rofecoxib Chronically Treated Mice, with IL1beta, Aorta RNA-Seq

Bulk RNA sequencing

We screen for vascular off-target effects at therapeutic concentrations of celecoxib and rofecoxib using genomic approaches in a mouse model of vascular inflammatory responses. We assess whether therapeutic concentrations of celecoxib and rofecoxib might elicit distinct genomic effects in vivo in mice by comprehensive and unbiased analysis of the whole transcriptome sequencing. Drug specific differences in their expression profiles would be indicative of off-target effects. SOURCE: Gregory,Robert,Grant (ggrant@upenn.edu) - ITMAT Bioinformatics University of Pennsylvania