During pregnancy, trophoblasts in the placenta are important in the success of pregnancy. We identify an adhesion molucule, JAM-C, which expresses on membrane of column cytotrophoblasts and regulates the differentiation and migration of trophoblasts. Primary cytotrophoblasts isolated from 1st trimester villi were transfected with JAM-C or control plasmids. RNA-seq analysis was sujected to identify differentially expressed genes and pathways potentially altered. SOURCE: Chenrui Cao (220183565@seu.edu.cn) -  Drum Tower Hospital

Pluto Bioinformatics

GSE156258: Genome-wide analysis of the JAM-C over-expressed trophoblasts