miRNA sponge, a special class of miRNA target,  has been emerging as a pivotal player in miRNA mediated regulatory network. Currently, the identified miRNA sponge genes mostly act on sequestering conserved miRNAs (e.g. miR-7, miR-145), however, the existence, potential function and evolutionary process of miRNA sponge genes for species-specific miRNA, especially for human specific miRNA, are largely unknown. In this study, we conducted a systematic analysis including sponge gene identification and subsequent function and evolutionary analyses for an authentic human-specific miRNA, miR-941. SOURCE: Haiyang Hu (huhaiyang@picb.ac.cn) - Integrative Biology/Comparative Biology PICB

Pluto Bioinformatics

GSE93716: Transfection experiment with vector containing TP73-AS1 sponge region and miR-941