Pluripotency is tightly regulated via versatile pathways and is crucial for the maintenance of stem cells and their implementation for regenerative medicine. Cyrano, a well conserved lncRNA, is highly expressed in stem cells suggesting an important role of Cyrano in pluripotency. Cyrano was previously described to be essential for the maintenance of mouse ESC pluripotency. In contrast, using different genetic models, we here found Cyrano to be dispensable in murine and human iPSCs and in human ESCs. RNAseq in human iPSC revealed only a moderate influence of Cyrano on the global transcriptome, pluripotency-related pathways remaining unaffected. SOURCE: Christian Bär (baer.christian@mh-hannover.de) -  Hannover Medical School

Pluto Bioinformatics

GSE150421: mRNA profiling after knockdown of lncRNA Cyrano