Pluto Bioinformatics

GSE142125: Inhibition of BRD4 Partially Rescues Dilated Cardiomyopathy and Cardiac Arrhythmias in Myocyte-Specific Lamin A/C Null Mice [RNA-Seq]

Bulk RNA sequencing

Deletion of Lmna, encoding nuclear membrane protein LMNA, specifically in mouse cardiac myocytes activates BRD4 and leads to heart failure, arrhythmias, myocardial fibrosis, apoptosis, and premature death, which were partially rescued upon inhibition of BRD4. SOURCE: Ali,J,Marian (Ali.J.Marian@uth.tmc.edu) - Marian Lab UTHSC, Houston