Abhd11 is previously identified as a conserved lipase in lipid metabolism. However, its physiological functions in embryonic stem cells (ESCs) are unknown. Based on the construction of ESC lines with conditional Abhd11 expression, we analyst the transcriptome profiling of ESCs upon Abhd11 knock-out (KO) or over-expression (OE). In Abhd11 KO ESCs, differentially expressed genes were enriched in metabolic genes while Abhd11 OE ESCs elicited a smaller transcriptional response compared to that of Abhd11 KO ESCs. SOURCE: Rui Jian (jianruilq2@aliyun.com) - Laboratory of Stem Cell and Developmental Biology Third Military Medical University

Pluto Bioinformatics

GSE142067: Gene expression of Abhd11 knock-out or over-expression embryonic stem cells