Pluto Bioinformatics

GSE144654: RNA sequencing analysis of WT- and Tet2-/-G17VRHOA-CD4 splenocytes

Bulk RNA sequencing

Angioimmunoblastic T-cell lymphoma, a subtype of T-cell lymphoma, is a disease with relative poor outcome. Genetic analysis in human samples showed the co-existence of common mutations in TET2 and RHOA genes. We have made a mouse model resembling the genetic lesions in human AITL. Our mice developed AITL-like lymphoma after 40 weeks old. We analyzed the expression of transcriptomes in WT- and Tet2-/-G17VRHOA-CD4 splenocytes to find out the underlying pathogenesis mechanism of AITL. SOURCE: Mamiko Sakata-Yanagimoto (sakatama-tky@umin.net) - University of Tsukuba