Pluto Bioinformatics

GSE101537: Neurog3-Cre p300/CBP mouse islets RNA-seq

Bulk RNA sequencing

We have performed RNA-seq on mouse islets lacking all p300 (p300 KO), all CBP (CBP-null), and one copy of CBP and all p300 (triallelic). The data revealed that p300 and CBP regulate some distinct but largely overlapping genes in islets. This was further confirmed by GO term and transcription factor target analyses, which suggested that these coactivators regulate genes that function similarly and converge to Hnf1a pathway. SOURCE: Chi Kin Wong (ckwong@cfri.ca) - Gibson BCCHR