Pluto Bioinformatics

GSE139964: RNA sequencing of Sphk1fl/fl Sphk2-/- and Sphk1-/- Sphk2-/- mESC clones.

Bulk RNA sequencing

We report a growth defect in sphingosine kinase null clones due to a cell cycle arrest in G2/M phase resulting in a growth defect. GSEA showed upregulation of the G2M checkpoint geneset. Further, telomere elongation factors are upregulated in kinase null cells. SOURCE: Kelly,Madigan,Banks (kmb2009@med.cornell.edu) - Todd Evans Lab Weill Cornell Medicine