Pluto Bioinformatics

GSE106389: RNAseq anaysis of ventral striatum cholinergic cells of p11 cKO mice

Bulk RNA sequencing

Purpose: To identify gene expression changes in cholinergic neurons of the ventral striatum of p11 cKO mice; Method: Translating Ribosome Affinity Purification (TRAP) to isolate RNA from ChAT+ cells and, cDNA synthesisi and next generation RNAseq using Illumina Hiseq sequencer.; Results: Biostatistical analysis identified 113 genes that were altered by p11. 59 genes were up-regulated and 54 down-regulated. SOURCE: Yotam Sagi Rockefeller University