Pluto Bioinformatics

GSE137945: Next Generation Sequencing of PKD2 mutant mice

Bulk RNA sequencing

Purpose: Determine the differential gene expression pattern between wildtype, Pkd2-KO and Pkd2-miR-214 KO mice; Methods: kidney mRNA profiles of Pkd2-KO and Pkd2-mir-214-KO mice was sequenced with N of 3 in each group; Results: 972 differentially expressed transcripts were identified between Pkd2-KO kidneys and Pkd2-miR-214-KO kidneys; Conclusion: Deletion of miR-214 promotes interstitial inflammation in mouse models of ADPKD SOURCE: Vishal Patel (vishald.patel@utsouthwestern.edu) - UTSW