Pluto Bioinformatics

GSE87321: Complete atrio-ventricular canal defects in mouse hearts lacking G-protein receptor kinases

Bulk RNA sequencing

Combined ablation of all 3 cardiac-expressed GRKs in the developing mouse heart impaired Hedgehog/Smoothened and GATA signaling, recapitulating heart abnormalities of human Complete Atrioventricular Septal Defect. SOURCE: Scot,J,Matkovich (smatkovich@gmail.com) - Washington University School of Medicine