Pluto Bioinformatics

GSE87200: Aurora B phosphorylates hnRNP U/SAF-A to facilitate XIST RNA removal from the inactive X chromosome during mitosis

Bulk RNA sequencing

We show that Aurora-B phosphorylates heterogeneous nuclear ribonucleoprotein U (hnRNP U) in the SAP domain to dissociate hnRNP U from chromatin during mitosis. We use RNA-seq to show that hnRNP U associates with hundreds of mRNAs and lncRNAs during interphase and mitosis. SOURCE: Michael,Demian,Blower (blower@molbio.mgh.harvard.edu) - Massachusetts General Hospital