Pluto Bioinformatics

GSE106338: Gene expression profiling study by RNA-seq in PDX model based diffuse type gastric cancers.

Bulk RNA sequencing

We established PDX lines from diffuse type gastric cancers (DGCs). Using these cells, we carried out RNA-seq based transcriptome profiling using 15 stomach samples including three PDX lines (HGC-3, HGC-8, and HGC-20) and normal-looking surrounding tissues. Via comparative analysis between cells and tissues, we identified significant gene set associated with each cell and observed that genes involved in AKT signalling pathway were commonly associated with all PDX lines. SOURCE: Seon-Kyu Kim (seonkyu@kribb.re.kr) - Korea Research Institutue of Bioscience & Biotechnology