Pluto Bioinformatics

GSE135318: DOT1L-mediated Murine Neuronal Differentiation associates with H3K79me2 Accumulation and preserves SOX2-Enhancer Accessibility

Bulk RNA sequencing

To study whether acute inhibition of DOT1L induces global chromatin states alterations, we profile and compare the transcriptome, chromatin accessibility and epigenome (H3K4me3, H3K4me1, H3K27ac, H3K27me3, H3K36me3, H3K9me3, H3K79me2) of mESC and ES-derived NPC, treated with DMSO or EPZ5676. SOURCE: Thomas Manke (manke@ie-freiburg.mpg.de) - Max Planck Institute of Immunobiology and Epigenetics

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