we reported for the first time a geroprotective effect of low-dose quercetin alone that improved the healthspan of aged C57BL/6J male mice. Que-treated mice showed less hair loss, greater athletic endurance, enhanced diastolicfunction, and less muscle fibrosis, as well as alleviated cellular senescence in multiple tissues. Interestingly, these changes appear to be rarely associated with transcriptional alterations of protein-coding genes but are linked to heterochromatin stabilization and RTE silencing. Que treatment prevented L1 from hyperactivation, thereby inhibiting SASP. SOURCE: Zunpeng Liu (zunpengliu@163.com) - Jing Qu State Key Laboratory of Stem Cell and Reproductive Biology

Pluto Bioinformatics

GSE132129: Low-dose quercetin positively regulates mouse healthspan