A subset of GC B cells that have stopped cycling, upregulated CD38 and downregulated BCL-6 is functionally verified as GC-derived memory B cell precursors (GC-MPs). RNA-seq analyses of the transcriptome were used to probe the developmental trajectory of these cells and their responses to IL-9, a cytokine that is found to drive the memory development from the GC. SOURCE: Hai Qi (qihai@mail.tsinghua.edu.cn) - Laboratory of Dynamic Immunobiology Tsinghua University

Pluto Bioinformatics

GSE85018: Germinal-center development of memory B cells driven by IL-9 from follicular helper T cells