The differentiation of nave CD4+ T cells into T helper (Th) subsets is key for a functional immune response and has to be tightly controlled by transcriptional and epigenetic processes. However, the function of cofactors that connect gene-specific transcription factors with repressive chromatin-modifying enzymes in Th cells is yet unknown. Here we determined transcriptional changes in Th17 cells upon deletion of the cofactor NCOR1. SOURCE: Wilfried Ellmeier (wilfried.ellmeier@meduniwien.ac.at) -  Medical University of Vienna

Pluto Bioinformatics

GSE138933: RNA-seq analysis of WT and NCOR1f/f,Cd4Cre in vitro-generated Th17 cells