Pluto Bioinformatics

GSE106246: An evolutionarily conserved ribosome-rescue pathway maintains epidermal homeostasis

Bulk RNA sequencing

mRNA quality control mechanisms ensure fidelity of protein translation. An evolutionarily conserved component of the quality control machinery, Dom34/Pelota (Pelo), rescues stalled ribosomes. Here we show that Pelo is required for mammalian epidermal homeostasis. Our study reveals a novel role for the ribosome-rescue machinery in mammalian tissue homeostasis and an unanticipated specificity in its impact on different stem cell populations. SOURCE: Fiona,M,Watt (fiona.watt@kcl.ac.uk) - King's College London