Pluto Bioinformatics

GSE81084: FOXO1 is an oncogenic mediator in AML1-ETO leukemia

Bulk RNA sequencing

Transcriptome analysis by RNAseq of human CD34+ hematopoietic stem and progenitor cells transduced with empty vector control(MIT), AML1-ETO (AE), wildtype FOXO1 (F WT) or FOXO1 DNA binding deficient mutant (F DB). We find wildtype FOXO1 partially recapitulates gene signature of AML1-ETO SOURCE: Shan LinJames Mulloy Cincinnati Children's Hospital Medical Center