Pluto Bioinformatics

GSE130735: Genome-wide roles of DNA methyltransferases in mouse embryos

Bulk RNA sequencing

Mouse embryos acquire global DNA methylation of their genome during implantation. However the exact roles of DNA methyltransferases (DNMTs) in embryognesis have not been studied comprehensively. Here we systematically analyze the consequences of genetic inactivation of Dnmt1, Dnmt3a and Dnmt3b on the methylome and transcriptome of mouse embryos and fibroblasts. SOURCE: Michael Weber CNRS