Chronic jet lag (CJL) induced by shifting light-dark cycles repeatedly is a commonly used protocol to mimic the environmental light/dark changes encountered by shift workers. We conducted RNA sequencing using prefrontal cortex (PFC) and nucleus accumbens (NAc) tissues from these animals, which are brains regions strongly implicated in the pathology of various neurological and psychiatric conditions. Our results reveal the alterations of brain activities and systematic reprogramming of gene expression in brain tissues under CJL, building hypothesis for how CJL increases the susceptibility to neurological and psychiatric diseases. SOURCE: Qian Gao (gao11235@126.com) -  Huazhong University of Science and Technology

Pluto Bioinformatics

GSE153540: Transcriptional profiling of mouse prefrontal cortex and nucleus accumbens under chronic jet lag