Pluto Bioinformatics

GSE80812: Klf5 regulates muscle differentiation via directly targeted muscle-specific genes in cooperation with MyoD

Bulk RNA sequencing

Deletion of Klf5 in satellite cells impaired muscle regeneration due to a failure of differentiation. Mechanistically, Klf5 controls transcription of muscle genes by interacting with MyoD and Mef2. These findings provide a potential intervention into the process of muscle regeneration through modulation of Klf5. SOURCE: Yumiko Oishi (yuooishi-circ@umin.ac.jp) - Tokyo Medical and Dental University