Pluto Bioinformatics

GSE130452: Examining the role of ATRX-RNA interactions in ATRX and PRC2 localization and gene expression.

Bulk RNA sequencing

We disrupted the RNA binding region in endogenous ATRX and tested localization of ATRX, EZH2 and H3K27me3 by CUT&RUN. We show that ATRX-RNA binding is important to regulate ATRX and PRC2 localization to specific genes. SOURCE: Kavitha Sarma The Wistar Institute