Pluto Bioinformatics

GSE101061: Oncogenic Serine-Threonine Kinase Receptor Associated Protein Supports Hepatocellular Carcinoma Cell Growth by Enhancing Wnt/-catenin Signaling

Bulk RNA sequencing

Serine-threonine kinase receptor-associated protein (STRAP) is upregulated in breast, colorectal and lung cancers, promoting their growth. We identify the upregulation of STRAP in hepatocellular carcinomas. Elevated STRAP endows tumor cells with growth advantage by reprograming a variety of metabolic processes and signaling pathways critical for hepatocellular carcinoma progression. Especially, enhanced Wnt/-catenin signaling is likely to be a major effector of its tumor-promoting role. SOURCE: Wenhui Wang (w.wang.1@erasmusmc.nl) - Erasmus MC