Pluto Bioinformatics

GSE105827: Common lymphoid progenitor derivation of plasmacytoid dendritic cells is mediated by Bcl11a

Bulk RNA sequencing

Plasmacytoid dendritic cells (pDC) specialize in type I interferon production to coordinate innate and adaptive immunity. We identify two pDC subsets in vivo, evaluate their genome-wide expression, and demonstrate a developmental requirement for Bcl11a to provide insight into this enigmatic cell type. SOURCE: Joseph,D,Dekker (joedekker@gmail.com) - University of Texas at Austin