Aggregation of hyperphosphorylated tau in neurofibrillary tangles (NFTs) is closely associated with neuronal death and the progression of cognitive deficits in Alzheimers disease (AD). Pathological tau appears to contribute to disease progression by disrupting axonal transport and synapse function; however, our understanding of the molecular alterations associated with tau aggregates and their cellular specificity remains limited. Here, we used single-cell transcriptomics to identify the precise neuronal subtypes that are susceptible to NFT development in the brains of AD patients and to characterize the molecular signatures that distinguish NFT-susceptible neurons from those that are aggregate-resistant. Our data provide an unprecedented resource for the identification of new biomarkers and targetable pathways in human AD. SOURCE: Inma Cobos (icobos@stanford.edu) -  STANFORD UNIVERSITY MEDICAL SCHOOL

Pluto Bioinformatics

GSE129308: Molecular signatures underlying neurofibrillary tangle susceptibility in Alzheimers disease