Differential gene expression profiling was performed in two lymphoblastoid cell lines with different radiosentivitity, one radiosensitive (RS) and another radioresistant (RR), after different post-irradiation times. A greater and a prolonged transcriptional response after irradiation was induced in the RS cell line. Functional analysis showed that 24 h after irradiation genes involved in DNA damage response, negative regulation of the cell cycle and apoptosis were still differentially up-regulated in the RS cell line but not in the RR cell line. SOURCE: Mireia Borràs-Fresneda (mireiaborras2@gmail.com) -  Universitat Autònoma de Barcelona

Pluto Bioinformatics

GSE80207: Transcriptome analysis in a radiosensitive and a radioresistant cell line after ionizing radiation