Pluto Bioinformatics

GSE80183: RNA-seq study reveals unique transcriptome expression in systemic lupus erythematosus patients with distinct autoantibody profile

Bulk RNA sequencing

Systemic lupus erythematosus patients exhibit remarkable heterogeneity in clinical manifestations and autoantibody repertoires. This complexity poses major barrier in diagnosis and effective treatment of SLE. To address this we studied the SLE patients in groups categorized on the basis of distinct sera autoantibodies. SLE patients were segregated into three group based on the presence of autoantibodies against i) dsDNA only ii) ENA (extractable nuclear antigens) only or iii) both. SOURCE: Geeta Rai (geetarair74@gmail.com) - Immunogenetics Banaras Hindu University