Pluto Bioinformatics

GSE100888: Transcriptional effects of motor neuron autophagy inhibition

Bulk RNA sequencing

To investigate the role of motor neuron autophagy in ALS, we generated mice in which the critical autophagy gene Atg7 was specifically disrupted in motor neurons (Atg7 cKO). We also bred these mice to the SOD1G93A mouse model of ALS. Then we performed RNA sequencing on lumbar spinal cords from these mice to determine how motor neuron autophagy inhibition altered gene expression. SOURCE: Paolo Guarnieri (p.guarnieri@hotmail.com) - Columbia University