Pluto Bioinformatics

GSE76315: Pax6 links H3K4 methylase activity to transcriptional regulation of Plekha1 through its distal enhancer

Bulk RNA sequencing

We performed ChIP-seq on mouse lens epithelial cells (TN4) and mouse newborn lens. Genome-wide binding sites of Pax6, H3K4me1, H3K4me2, H3K4me3, and RNA polymerase II were generated. We also performed RNA-seq on TN4 cells treated with Pax6 and control shRNAs. SOURCE: Rodrigo,A. P.,Martins (rodrigomartins007@gmail.com) - Dr. Martins lab Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil