Pluto Bioinformatics

GSE126770: Natural genetic variation reveals key features of epigenetic and transcriptional memory in virus-specific CD8 T cells

Bulk RNA sequencing

Stable changes in chromatin states and gene expression in cells of the immune system form the basis for their memory of infections and other challenges. We used naturally occurring cis-regulatory variation in wild-derived inbred mouse strains to explore the mechanisms underlying long-lasting vs. transient gene regulation in antigen-specific CD8 T cells responding to acute viral infection. Our observations provide novel insights into the mechanisms driving stable and reversible transcriptional and epigenetic memory in virus-specific CD8 T cells. These findings suggest a general mechanism for the formation of epigenetic memory in CD8 T cells and other immune and non-immune cells. SOURCE: Yi Zhong (zhongy@cbio.mskcc.org) - Memorial Sloan Kettering Cancer Center