Pluto Bioinformatics

GSE129045: YAP and AP-1 cooperate to initiate rapid pancreatic cancer development from the ductal cell population in mice

Bulk RNA sequencing

Purpose: We aimed to elucidate the unique consequences of YAP/TAZ activation in pancreatic ductal cells.; ; Methods: We isolated RNA from Lats1 and Lats2 double knockout ductal cells from Lats1fl/fl; Lats2fl/fl; Sox9-CreER mice.; ; Results: Oncogenic activation of YAP in ductal cells lead to the rapid development of carcinoma in situ with microinvasion. SOURCE: David Eisenbarth ( - KAIST

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