We used genome-wide sequencing methods to identify activity-regulated gene expression and regulatory elements in human neurons.  Sensory stimuli drive the maturation and function of the mammalian nervous system in part through the activation of gene expression networks that regulate synapse development and plasticity.  These programs of gene transcription have primarily been studied in mice, and it is not known if there are neuronal activity-regulated genes that control features of brain development and function that are unique to humans.  In this study, we used genome-wide sequencing methods to identify activity-regulated gene expression and regulatory elements in human neurons. SOURCE: Bulent AtamanMichael E. Greenberg Harvard Medical School

Pluto Bioinformatics

GSE78688 (mouse): Activity-dependent transcriptional changes in human neurons