Pluto Bioinformatics

GSE125223: Paradoxical CD4 decline on ART: a novel, rare and perplexing immunologic outcome

Bulk RNA sequencing

The goal of antiretroviral therapy (ART) is to suppress HIV-1-replication and reconstitute CD4-T-cells. Here, we report on HIV-infected individuals, who had a paradoxical decline in CD4-T-cells despite ART-mediated suppression of plasma HIV-1 load (plHIV-1). We defined such immunological outcome as extreme immune decline (EXID). SOURCE: Craig Martens (martensc@niaid.nih.gov) - NIAID