N6-methyladenosine (m6A) is the most common internal modification in eukaryotic messenger RNA (mRNA). The effects of this reversible cheimcal modification are mediated in part by methyl-specific RNA binding protein 'readers' of the YTH family. In this study we present the function of YTHDC1 (YT521) in promoting the export of mRNA from the nucleus to the cytoplasm. Additionally, we identify a role for YTHDC1 in exon retention in mouse embryonic stem cells (mESCs). SOURCE: Ian Roundtree (iroundtree@uchicago.edu) - Chuan He Lab University of Chicago

Pluto Bioinformatics

GSE74397 (mouse): N6-methyladenosine-Mediated Nuclear Export of Messenger RNA