Pluto Bioinformatics

GSE124369: Inducible bronchus-associated lymphoid tissues (iBALT) serve as sites of B cell selection and maturation following influenza infection in mice

Bulk RNA sequencing

GC-like structures within iBALT serve as a distinct niche that independently support the maturation and selection of B cells primarily targeted against the influenza virus nucleoprotein. Our findings suggest that iBALT, which are positioned at the frontline of the lung mucosa, drive long-lived and unique GC reactions that contribute to the diversity of the humoral response targeting influenza. SOURCE: Hyon Xhi Tan (hxtan@unimelb.edu.au) - The University of Melbourne, at the Peter Doherty Institute for Infection and Immunity