Pluto Bioinformatics

GSE67112: The Expansion of Thymopoiesis in Neonatal Mice is Dependent on Expression of High mobility group A 2 protein (Hmga2)

Bulk RNA sequencing

The most immature progenitors in the murine thymus are early T lineage progenitors (ETP). These cells are the precursors of more mature thymocytes that ultimately leave the thymus and colonize peripheral lymphoid tissues. As part of our efforts to define age-related changes in ETP, we harvested them from mice of different ages and performed whole transcriptome profiling. This analysis revealed major differences in patterns of gene expression between young and old ETP, and we were particularly struck by the significantly reduced expression of the gene encoding high mobility group A 2 protein (Hmga2). SOURCE: Kenneth Dorshkind (kdorshki@mednet.ucla.edu) - David Geffen School of Medicine at UCLA