Pluto Bioinformatics

GSE85671: The Genomic Landscape of Atypical Fibroxanthoma

Bulk RNA sequencing

In this study, we used exome sequencing and RNA sequencing to describe the genomic landscape of Atypical Fibroxanthoma (AFX). Using exome sequencing data, we identified several genes commonly mutated in our samples such as CSMD3, COL11A1, and FAT1. We also identified deletions in chr9p and chr13q in the AFX tumors. Using our RNA-sequencing data, we identified 8591 differentially expressed genes, of which 3524 genes had at least a 2 log fold change between AFX tumors and normal keratinocytes. We also identified several pathways that are dysregulated in AFX, such as epithelial to mesenchymal transition and tumor-associated macrophage response. SOURCE: Kevin Lai (Kevin.Lai@ucsf.edu) - University of California, San Fransico