Pluto Bioinformatics

GSE100743: Gene Expression Profiling of SPOP Knocked Down Cell

Bulk RNA sequencing

SPOP is one of the most frequent mutated genes in prostate cancer. In the current study, we identified CCNE1 as its substrate. SPOP directly interacts with CCNE1, poly-ubiquitinates CCNE1 in vivo and in vitro, and represses cancer-related phenotypes induced by CCNE1 expression. Thus, we reveal a new mechanism for SPOP in repressing prostate cancer tumorigenesis. SOURCE: Pinji Lei (leipinji@gmail.com) - Epigenomics Wuhan University