Pluto Bioinformatics

GSE105043: IL-1R8 is a checkpoint in NK cells regulating anti-tumor and anti-viral activity

Bulk RNA sequencing

We reported that IL-1R8 serves as a checkpoint for NK cell maturation and effector functions. Its genetic blockade unleashes NK-cell mediated resistance to hepatic carcinogenesis, hematogenous liver and lung metastasis and cytomegalovirus infection. SOURCE: Cecila GARLANDA Humanitas clinical and Research Center