This dataset consists of hepatic gene expression profiles of mice subjected to 4 compounds predicted by Connectivity Map (CMap) using gene signatures identified for known lifespan-extending interventions: ascorbyl-palmitate, KU-0063794, AZD8055 and rilmenidine. Corresponding age-, sex- and strain-matched littermate controls are also presented.  Using this data, we confirmed the association between longevity signatures and gene expression response to the predicted compounds in vivo, using the same mouse model as for the identification of gene signatures associated with lifespan extension. This pilot project demonstrated the applicability of such approach for the discovery of new interventions with a desirable effect on gene expression and provided appealing candidates for further longevity studies. SOURCE: Maxim Gerashchenko (mgerashchenko@bwh.harvard.edu) -  Brigham and Women's Hospital

Pluto Bioinformatics

GSE131868: RNA sequencing of mouse hepatic response to compounds with predicted lifespan-extending effect