Pluto Bioinformatics

GSE66160: RNA-seq on mouse E11.5 ventral midbrain neurosphere cultures treated with the LXR agonist GW3965 and the GSK3beta inhibitor CT99021

Bulk RNA sequencing

We investigated mechanisms by which LXRs regulate midbrain dopaminergic neuron development. Using a systems biology approach, we found that LXR interacts with -catenin and that LXR activation inhibits the activity of the Wnt/-catenin pathway SOURCE: Sten LinnarssonMolecular Neurobiology Karolinska Institutet