Pluto Bioinformatics

GSE104956: LEAP2 is an Endogenous Antagonist of the Ghrelin Receptor

Bulk RNA sequencing

Bariatric surgery, an effective treatment for obesity and diabetes, leads to profound remodeling of whole body energy homeostasis. We utilized a mouse model of vertical sleeve gastrectomy (VSG), a common bariatric surgery as a tool to identify novel secreted proteins and peptides that might act as important metabolic regulators. We analyzed gene expression in the stomach and intestines following VSG or sham surgery in diet-induced obese mice and sought to identify differentially regulated genes encoding secreted proteins/peptides. SOURCE: Daniel,David,Kaplan NGM Biopharmaceuticals

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